WHAT IS MPS?

MPS disorders are a group of rare, genetic, inheritable, metabolic diseases, which form part of the lysosomal storage diseases (LSDs)^14-17

• They affect males and females equally (with the exception of MPS II, which mainly affects males) and can be as common as ~1 in 25,000 live births (with prevalence varying by region and ethnic background)^16,18
• MPS disorders are caused by a deficiency in enzymes responsible for degrading glycosaminoglycans (GAGs) [see table below]. As a result, GAGs accumulate in the lysosomes of many of the bodys cells, causing progressive damage throughout the body^14-17
• Multiple organs and systems can be involved, including the cardiovascular, skeletal, respiratory and neurologic systems¹⁶
• Having an MPS disorder can lead to organ failure, cognitive impairment and reduced life expectancy^16,17

To date, 11 different enzymatic deficiencies are known to cause seven MPS disorders:^15-17 For more information about MPS, please visit www.MPSReference.com.